The precision with which different molecular processes are regulated at various stages of development is extraordinary. Evolution has established different levels of regulation to acquire and maintain desired cell state. The expressed genes in a cell define its fate. The epigenetic state, transcriptional and post-transcriptional programs are crucial regulators of gene expression levels. To develop next-generation of therapeutics, an understanding of the complex transcriptional, co-transcriptional and post-transcriptional mechanisms driving cell fate are required. Firstly, I will demonstrate how in absence of genetic mutations cancer cells hijack the molecular machinery to dysregulate co-transcriptional RNA processing for driving tumorigenesis. We found intronic polyadenylation as a novel mechanism for functional inactivation of tumor suppressor genes. Secondly, I will discuss the role of epigenetics in altered gene expression program to support growth and differentiation of cancer stem cells. Changes in the epigenome can lead to acquisition of large clusters of active enhancers, also referred as “super-enhancers”. Super-enhancers are in the proximity of oncogenes resulting in multi-fold increase of their expression levels. Many of these super-enhancers drive expression of transcription factors which in turn can directly regulate the expression of other oncogenes. We found existence of distinct super-enhancer states in cancer stem cell drives distinct tumor subtypes. I will also discuss the ongoing work and the future direction in the laboratory. Join Zoom Meeting https://zoom.us/j/97345224277?pwd=cWY1azZYdzFhdHdxYmVJWG92MTFrUT09 Meeting ID: 973 4522 4277 Passcode: 997269

In this talk, we summarize the application of $SU(3)$-flavor symmetry to bottom baryons decaying into a decuplet or octet baryon and a pseudoscalar meson. Our approach facilitates an $SU(3)$ decomposition of the decays in terms of $SU(3)$-reduced amplitudes without resorting to assumptions about the underlying dynamics. Making use of the Standard Model effective Hamiltonian mediating $b$-quark weak decays, several amplitude relations and $CP$ asymmetry relations are derived for bottom baryons decaying to an octet or decuplet light baryon and an octet meson. Once $CP$-asymmetry is measured in some of these related decay modes, it can serve as a test of $SU(3)$-symmetry and $SU(3)$-breaking effects can be studied systematically. Moreover, we hope to estimate the unknown $SU(3)$ parameters directly from the data once a substantial number of these decay observables are measured in the near future. Google Meet joining info Video call link: https://meet.google.com/orp-xrmy-akq Or dial: ‪(US) +1 470-273-8493‬ PIN: ‪197 355 293‬#