IMSc Webinar

Effects of active perturbations on chromatin organization and regulation

Jyotsana Jewel Parmar

NCBS Bangalore / University of Warwick, UK

Chromatin carries genetic information and is made of long polymers of DNA-protein assemblies compacted at different levels and enclosed inside the nucleus. Apart from functioning as the information bearer, chromatin also integrates external signals and regulates the manifestation of this information. It has been shown by various studies that chromatin organization is dynamic, however, shows several non-random features which are driven by both active and passive components. Different regulatory processes e.g., chromatin remodelling, transcription activation and silencing, DNA repair etc., modify the 3D- genome organization. In this work, I will study how these dynamic processes which act locally, at nucleosome/gene level, would affect the overall global chromatin organization. My approach will be to integrate active mechanics and polymer-physics based models with experimental data obtained from sequencing (such as Hi-C and ChIP-seq) and imaging techniques.

zoom.us/j/97239618248

Meeting ID: 972 3961 8248
Passcode: 588184