IMSc Webinar

Detection and characterization of rare transcriptomes

Debarka Sengupta

IIIT-Delhi

[Google Meet Link]: meet.google.com/qhg-assc-wxg

[Download title and abstract of the talk]: www.imsc.res.in/~asamal/seminar/DebarkaSengupta_Sep15_2020.pdf

[Abstract]:
Over the past decade, single-cell transcriptomics has transcended our understanding of complex biological systems. Single-cell expression readouts allow precise characterization of cellular heterogeneity in normal as well as diseased tissues. Further, single-cell RNA sequencing allows the detection of cells, present in a minority within a tissue. Examples of rare cell types include circulating tumor cells, cancer stem cells, circulating endothelial cells, endothelial progenitor cells, antigen-specific T cells, invariant natural killer T cells, etc. In practical scenarios, rare cell detection poses significant methodological challenges. In this talk, I will discuss our group's journey of raising a new breed of computational techniques for the efficient detection of rare transcriptomes.