Wednesday, May 11 2022
16:00 - 17:00

IMSc Webinar

Building the cell from unreliable parts: the case of stochastic organelle biogenesis

Prof. Shankar Mukherji

Washington University

Perhaps the defining feature of the eukaryotic cell is its
organization into membrane-bound compartments known as organelles.
While the processes underlying the biogenesis of individual organelles
are often well-known, the precision with which individual cells exert
quantitative control over individual organelle properties, such as
number and size, and coordinate these properties at systems-scale
across the cell’s many different types of organelles remain frontier
problems in cell biology and biophysics. Using a combination of theory
and quantitative experiment, I will describe our recent efforts to
show that cells exhibit substantial limits to the precision with which
they can control organelle numbers and sizes, but despite this appear
to collectively organize organelle biogenesis into specific “modes”
when faced with the need to respond to environmental and genetic

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Meeting ID: 980 8637 5243
Passcode: 644449

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