| Abstract | Understanding the physical principles governing chromatin organization is an important problem in cell biology. We propose phase separation of DNA-binding proteins as a possible mechanism influencing chromatin organization. We use a simple polymer model of chromatin and interacting particles as DNA-binding proteins. We show that by tuning the concentration of DNA-binding proteins and protein-protein interaction, it is possible to reconcile the apparent discrepancies between existing models. In the second part, I will discuss the forces involved in DNA-protein cocondensation and the role of DNA sequence heterogeneity. I will end the talk by stating an ongoing work about the interplay of gene expression noise and phase separation. |