Research Scholars Annex Hall

Genome-wide Reprogramming Events that Establish Transcriptional Regulatory Code

K Natarajan

School of Life Sciences, JNU, New Delhi

Living cells respond to stress signals by global reprogramming of transcription. In the first part of my talk, I would discuss our functional genomics studies in the pathogenic Candida genomes that uncovered the role of novel TAF12 variants, specifically that of the SAGA-specific TAF12 variant in fungal pathogenesis and oxidative stress response.

In the second part, I would discuss the transcriptional regulatory codes underlying skin pigmentation. Here I would describe our ongoing studies that identified transcriptional regulatory networks that specifies melanogenesis in a mouse cell-based model of skin pigmentation.

References:

Sinha, I., Kumar, S., Poonia, P., Sawhney, S., Genevan, K. and Natarajan, K. (In submission). Two Novel TAF12 Variants Uniquely Associate with TFIID and SAGA and Confer Specificity of Gene Regulation in the human fungal pathogen Candida albicans

Saint, M*, Sawhney, S*, Sinha, I, Singh R.P., Thakur, A., Siddharthan, R. and Natarajan K. (2014). TAF9 C-terminal conserved region domain is required for SAGA and TFIID promoter occupancy to promote transcriptional activation. Molecular and Cellular Biology 34(9): 1547-63.

Priyadarshini, Y. and Natarajan K. (2016). Reconfiguration of Transcriptional Control of Lysine Biosynthesis in Candida albicans Involves a Central Role for the Gcn4 Transcriptional Activator. mSphere (ASM Press) Jan 2016