Alladi Ramakrishnan Hall

Transcriptional Enhancers – Looking out for the genes and each other

Sridhar Hannenhalli

University of Maryland / visiting IISc Bangalore

The ENCODE project, via generation of unprecedented
transcriptomic and epigenomic profiles, has revealed a complex layer of
transcriptional regulation mediated by distal regulatory enhancers
distributed throughout the human genome. These data open up more
questions than they answer. We will discuss their nuclear organization,
how they can be used for better genotype-phenotype associations and
their potential emergent properties by virtue of their spatial
proximity.