Monday, June 17 2024
14:00 - 16:00

Alladi Ramakrishnan Hall

Phase separation influences chromatin structure, dynamics and gene expression noise

Pinaki Swain


Abstract: Understanding the physical principles governing chromatin organization is an important problem in cell biology. We propose phase separation of DNA-binding proteins as a possible mechanism influencing chromatin organization. We use a simple polymer model of chromatin and interacting particles as DNA-binding proteins. We show that by tuning the concentration of DNA-binding proteins and protein-protein interaction, it is possible to reconcile the apparent discrepancies between existing models. In the second part, I will discuss the forces involved in DNA-protein cocondensation and the role of DNA sequence heterogeneity. I will end the talk by stating an ongoing work about the interplay of gene expression noise and phase separation.

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