| * Venue | E C G Sudarshan Hall |
| * Speaker | Mukund Thattai |
| * Title | Regulatory and Evolutionary Landscape of Eukaryotic Vesicle Traffic |
| Affiliation | NCBS Bangalore |
| Abstract | In all eukaryotic cells, transport vesicles move cargo between membrane-bounded compartments such as the ER, Golgi, and plasma membrane. We are interested in understanding how the topology of this vesicle traffic network arises from molecular interactions. The loading of cargo into budding vesicles, and the fusion of these vesicles to target compartments, is regulated by modules of interacting proteins such as coats, cargo adaptors, and fusogenic SNARE proteins. The system is self-organised, because the resulting flux of cargo determines the composition of each compartment. We explore a rule-based multilevel model of vesicle traffic involving three layers: evolutionary (genes), regulatory (protein interactions), and phenotypic (cargo transport graph). Given a transport graph, we can efficiently determine the regulatory interactions that are necessary and sufficient for its existence. This framework allows us to predict the set of interacting molecular players needed to support any given transport graph. It can be useful in exploring phenomena such as the re-wiring of vesicle traffic by mutations, or by pathogens. Zoom: zoom.us/j/97126588990 Meeting ID: 971 2658 8990 Passcode: 098619 |
| * Announcement? | Institute |
| * Refreshments? | None |
| * Honorarium? | Professor |
| Special Arrangements? | None |
| * Host name and email |